Yes there is difference, read the following
IELTS General for the candidates who opt medical/ healthcare and other professionals wishing to work in a native English-speaking country. In IELTS General the writing module task may differ and it includes only general letter writing.
IELTS Academic
The candidates who are planning to study abroad can opt this course, In IELTS academic the writing module take may focus on report writing (Pic/bar charts, case study and etc) rest all other modules will follow the same test procedures and it won’t differ both in IELTS General and Academic